An Age Dependent Seizure Vulnerability of Hippocampal CA2: Finding the Targets to Rescue Seizure-Induced Social Recognition Memory Deficits
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Early life seizures (ELS) pose a significant threat to developing neurons and often result in later-life epilepsy and cognitive deficits, including social cognition deficits. Hippocampal CA2 has recently emerged as a critical region in processing social recognition memory. Little is known about the effects of ELS on CA2 pyramidal neurons in the developing hippocampus. Here, using established ELS models, we demonstrated that ELS impaired social recognition memory in mouse pups. We showed that unlike the adult CA2 neurons, ELS significantly activated CA2 neurons in p10 mice. Interestingly, ELS selectively enhanced AMPA receptor function in the activated CA2 neurons in the immature brain . Using a unique actviatiy-dependent labeling and manipulating system, c-Fos-GFP/c-Fos-tTA/TRE-hM4Di mouse model, we discovered that precisely suppressing ELS-activated neurons rescued ELS-induced AMPAR function enhancement in CA2 neurons and social recognition memory deficits. Our results identify the novel cellular target of ELS for potential intervention of ELS-induced cognitive deficits.
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Copyright © 2022 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2022
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correa-anagedependentseizurevulnerabilityofhippocampal.pdf | 2023-05-05 | Public | Download |