Examining Neuroendocrine and Inflammatory Biomarker Profiles to Characterize PTSD Subtypes and Symptom Profiles.

Post-traumatic stress disorder (PTSD) is a multifaceted mental health disorder characterized by diverse clinical and biological profiles. Participants in the current study comprised individuals with PTSD who had military experience and healthy controls. All participants completed questionnaires assessing mental health symptoms and provided saliva and blood samples for cortisol and inflammatory marker determination. The dissociative PTSD group displayed the highest symptom severity, reflecting a high degree of comorbidity, in addition to elevated traumatic life encounters, including experiences of childhood abuse. Individuals with dissociative PTSD had elevated nighttime cortisol, whereas the non-dissociative PTSD group did not differ from controls, while both PTSD groups showed elevated cortisol awakening response. Inflammatory levels were associated with clinical symptomatology and childhood traumatic experiences. This suggests that PTSD subtypes may be differentiated on a clinical and neurobiological level. Further delineation of the biological underpinnings of these subtypes can inform personalized treatment strategies for individuals with PTSD.