The long-Term Effect of Juvenile Stressor Exposure and Access to Palatable Food: Alterations in Dopamine and Ghrelin Signalling
Public Deposited- Resource Type
- Creator
- Abstract
Juvenile stressor exposure induces anxiety-like characteristics in adulthood and it is thought that palatable food can dampen HPA-activity, in part, through the mesolimbic pathway. Ghrelin, an orexigenic peptide, is involved in stress-induced preference for palatable food by modulating dopamine activity in the reward pathway. We hypothesize that the combination of juvenile stress and palatable food sensitizes the reward pathway, which will be manifested by altered dopamine signalling and enhanced sensitivity to ghrelin in adulthood. Findings revealed that palatable food ameliorated the anxiogenic effects of juvenile stress in adulthood however at the cost of increased adiposity. Also, a lack of association between the upregulation of dopamine receptor mRNA expression occurring at nucleus accumbens to rewarding stimuli (cookie dough and cocaine) in previously stressed rats fed the palatable food was observed. Juvenile stressor exposure enhanced ghrelin signalling for hedonic food whereas access to palatable food, regardless of stressor exposure, blunted ghrelin sensitivity.
- Subject
- Language
- Publisher
- Thesis Degree Level
- Thesis Degree Name
- Thesis Degree Discipline
- Identifier
- Rights Notes
Copyright © 2015 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Date Created
- 2015
Relations
- In Collection:
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
ali-thelongtermeffectofjuvenilestressorexposure.pdf | 2023-05-04 | Public | Download |