Regional Blood Flow Alterations Following Pediatric Concussion: A PedCARE+MRI Substudy
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This study examined whether cerebral blood flow (CBF) differed between children with concussion and orthopedic injury (OI) controls at 72 hours and 4 weeks post-injury. It also examined whether acute CBF and psychological resilience improved prediction of concussion symptoms beyond the existing 5P score prediction tool. 70 children with concussion (Mean age=13.05±2.02, 47% female) and 29 with OI (Mean age=12.59±1.97, 41% female) were included in this study. Regional CBF alterations were present in children with concussion versus OI, with some regional CBF varying over time. Specifically, increased CBF was found in anterior regions, and decreased CBF was found in posterior/temporal regions. Regional CBF, psychological resilience, and the 5P score combined did not predict 2- or 4-week concussion symptoms. Though clinical significance remains unclear, these results are important for understanding persistent neurobiological deficits after pediatric concussion, as they indicate clear regional CBF alterations.
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Copyright © 2022 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2022
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kardish-regionalbloodflowalterationsfollowingpediatric.pdf | 2023-05-05 | Public | Download |