Long Term Effects of Early Life Maternal Separation During Tyrosine Receptor Kinase B (TrkB) Knockdown
Public Deposited- Resource Type
- Creator
- Abstract
Recent work suggests that depression may be a disorder of neuroplasticity. Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that signals through tyrosine receptor kinase B (TrkB) to influence synaptic growth and maintenance, and has been implicated in depression. Early life stressors are known to predispose individuals to the later development of depression. We hypothesized that this predisposition is mediated by TrkB/BDNF signalling in early life. Therefore, we utilized a TrkB mutant mouse (TrkBF616A) to reversibly block early postnatal BDNF/TrkB signalling during exposure to early life stress (maternal separation). In 3 month-old mice exposed to maternal separation, we found that TrkB knockdown impacted various aspects of their apparent resiliency to stress in adulthood. Moreover, these mice have very circumscribed variations in the expression of TrkB and BDNF within the brain. We speculate that BDNF might imprint early life stressor events, which ultimately influences the manifestation of depressive illness.
- Subject
- Language
- Publisher
- Thesis Degree Level
- Thesis Degree Name
- Thesis Degree Discipline
- Identifier
- Rights Notes
Copyright © 2017 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Date Created
- 2017
Relations
- In Collection:
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
prowse-longtermeffectsofearlylifematernalseparation.pdf | 2023-05-05 | Public | Download |