Associations Between Long Term Exposure to Air Pollution and the Incidence of Dementia and Cognitive Impairment in a Canadian Prospective Cohort Study

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Yu, Yanjiang




The analyses revealed that PM2.5 was somewhat positively associated with the development of dementia, Alzheimer’s, and CIND. Specifically, the adjusted hazard ratios (HR) in relation to a 10 μg/m3 increase in PM2.5 for these three conditions were: 1.15 (95% CI=0.93-1.40), 1.32(95% CI=0.95-1.83) and 1.52 (95% CI=1.20-1.95), respectively. In contrast, NO2 concentrations were not associated with any of these three outcomes. The corresponding hazards ratios for a 5 ppb increase in NO2 for dementia, AD, and CIND were 0.98 (95% CI=0.93-1.03), 1.00(95% CI=0.91-1.09) and 0.99 (95% CI=0.83-1.06), respectively. Our findings also suggest that the association between PM2.5 and our measures of dementia are stronger among those who are obese when compared to those who are not.






Carleton University

Thesis Degree Name: 

Master of Science: 

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Thesis Degree Discipline: 

Probability and Statistics

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Theses and Dissertations

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