Associations Between Long Term Exposure to Air Pollution and the Incidence of Dementia and Cognitive Impairment in a Canadian Prospective Cohort Study
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The analyses revealed that PM2.5 was somewhat positively associated with the development of dementia, Alzheimer’s, and CIND. Specifically, the adjusted hazard ratios (HR) in relation to a 10 μg/m3 increase in PM2.5 for these three conditions were: 1.15 (95% CI=0.93-1.40), 1.32(95% CI=0.95-1.83) and 1.52 (95% CI=1.20-1.95), respectively. In contrast, NO2 concentrations were not associated with any of these three outcomes. The corresponding hazards ratios for a 5 ppb increase in NO2 for dementia, AD, and CIND were 0.98 (95% CI=0.93-1.03), 1.00(95% CI=0.91-1.09) and 0.99 (95% CI=0.83-1.06), respectively. Our findings also suggest that the association between PM2.5 and our measures of dementia are stronger among those who are obese when compared to those who are not.
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Copyright © 2016 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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