Associations Between Long Term Exposure to Air Pollution and the Incidence of Dementia and Cognitive Impairment in a Canadian Prospective Cohort Study

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Creator: 

Yu, Yanjiang

Date: 

2016

Abstract: 

The analyses revealed that PM2.5 was somewhat positively associated with the development of dementia, Alzheimer’s, and CIND. Specifically, the adjusted hazard ratios (HR) in relation to a 10 μg/m3 increase in PM2.5 for these three conditions were: 1.15 (95% CI=0.93-1.40), 1.32(95% CI=0.95-1.83) and 1.52 (95% CI=1.20-1.95), respectively. In contrast, NO2 concentrations were not associated with any of these three outcomes. The corresponding hazards ratios for a 5 ppb increase in NO2 for dementia, AD, and CIND were 0.98 (95% CI=0.93-1.03), 1.00(95% CI=0.91-1.09) and 0.99 (95% CI=0.83-1.06), respectively. Our findings also suggest that the association between PM2.5 and our measures of dementia are stronger among those who are obese when compared to those who are not.

Subject: 

Statistics

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Probability and Statistics

Parent Collection: 

Theses and Dissertations

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