Development of a Method for Registering Surface of Left Atrium determined by LGE-MRI to Electroanatomical Maps
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Abnormal electrical conduction and excitability associated with fibrosis in the left atrium (LA) may serve as a substrate for atrial fibrillation (AF). Electroanatomical voltage mapping systems (EAMs) have become a dominant facilitator to treat AF with surgical ablation assisted by additional diagnostic imaging modalities. Importantly, AF has been associated with structural changes to the extracellular matrix of the myocardium, including increased collagen deposition-a process known as fibrosis. Late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) may aid in guiding AF cardiac ablation therapy by determination of fibrosis in the LA. To locate fibrosis for cardiac ablation, however, precise registration between EAMs and LGE-MRI data is crucial. The purpose of this thesis was to develop a method for registering EAMs with late gadolinium-enhanced magnetic resonance image (LGE-MR) images.
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Copyright © 2018 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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