A Personalized Approach to Understanding Depression: Examining the Biological and Psychosocial Basis of Symptom Clusters
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Despite the prevalence and impact of depression, effective treatments lag behind that of many physical conditions owing, in part, to the complexity of this disorder. Considering the heterogeneity of depression and comorbidities with other mental illnesses, a focus on the symptoms expressed and how these relate to psychosocial and biological factors, may inform a personalized treatment strategy. We developed transdiagnostic symptom clusters spanning boundaries of anxiety and depression that mapped onto specific psychosocial and biological factors. Namely, clusters representing the neurovegetative features of depression strongly related to inflammatory profiles, suggesting that this relationship is symptom specific. Moreover, clusters representing comorbid symptomatologies were associated with increased severity of symptoms, higher early life adversity scores and suicidal behaviours. The present study suggests distinct symptomatologies have differing biological underpinnings. Thus, shifting away from diagnostic categories and further exploring personalized approaches to better understand the neurobiology of depression and inform future treatments is warranted.
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Copyright © 2020 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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franklyn-apersonalizedapproachtounderstandingdepression.pdf | 2023-05-05 | Public | Download |