An investigation of beta-adrenergic receptor involvement in amygdala kindling
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The role of the beta adrenergic receptor subtype in the development and expression of kindled seizures was examined in vivo. Male Wistar rats received acute administrations of isoproterenol, a beta receptor agonist, or propranolol, a beta receptor antagonist, in doses of 0.5, 1.0 or 10.0 mg/kg 30 minutes prior to each kindling trial.Isoproterenol initially lowered seizure thresholds while decreasing AD durations. In addition, this agent exerted profound retardative effects upon the development of kindling to fully generalized convulsions. Conversely,blockade of beta receptors with propranolol initially raised thresholds for seizure while exerting no effects on initial AD durations. Furthermore, animals treated with this drug progressed to fully generalized seizures more rapidly than isoproterenol-treated animals.These results are interpreted as evidence that different subpopulations of beta-adrenergic receptors mediate different seizure-related effects at various stages in the development of kindled convulsions.
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This work is available on request. You can request a copy at https://library.carleton.ca/forms/request-pdf-copy-thesis
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Copyright © 1985 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 1985
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