An Iterative-Triple-Energy Window Approach to Cross-Talk Correction in Quantitative Small Animal Tc-99m and In-111 Single Photon Emission Computer Tomography

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.


Prior, Paul




Dual isotope Single Photon Emission Computed Tomography permits in vivo measurements of two separate signals simultaneously, but the quantitative accuracy of these measurements is degraded due to the presence of cross-talk. An iterative triple energy window method was developed to correct for cross-talk in In-111 and Tc-99m dual isotope SPECT. The correction was evaluated in comparison to other TEW-based methods in phantoms and in vivo. In phantoms containing different (Tc-99m)/(In-111) activity fractions, scattered In-111 photons falsely detected as Tc-99m resulted in an over-estimation of
Tc-99m activity by up to 80%. Application of the iterative TEW resulted in quantification of total Tc-99m activity within 5% of the truth across the largest range of activity fractions. In vivo, modified and iterative TEW both quantified total heart Tc-99m activity within 5% in a rat, but the iterative TEW was superior to the modified TEW in removing cross-talk in regions of mostly In-111.


Physics - Nuclear
Biophysics - Medical




Carleton University

Thesis Degree Name: 

Master of Science: 

Thesis Degree Level: 


Thesis Degree Discipline: 


Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).