Functional connectivity from Zona Incerta Cells Coexpressing Dopamine and GABA to the Superior Colliculus
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The zona incerta is important for anxiety-mediated behaviors. It contains a group of dopaminergic cells that coexpress the vesicular GABA transporter, potentially coreleasing dopamine and GABA. The superior colliculus is a known projection site of the zona incerta and supports anxiety-driven behavior. However, it is not known if dopaminergic zona incerta cells innervate the superior colliculus via dopamine and GABA transmission. We expressed channelrhodopsin in zona incerta neurons of Th-cre mice, and their fibres were restricted to the medial motor-related layers of the superior colliculus. The superior colliculus cells received monosynaptic GABA transmission from the zona incerta, and these connected cells were dopamine responsive. These results indicated a direct connection between the zona incerta dopamine-GABA cells and the medial motor layers of the superior colliculus. These results are important in understanding the role of the zona incerta dopamine-GABA cells in the regulation of anxiety-related behaviors in the superior colliculus.
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Copyright © 2021 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2021
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schumacker-functionalconnectivityfromzonaincertacells.pdf | 2023-05-05 | Public | Download |