Functional connectivity from Zona Incerta Cells Coexpressing Dopamine and GABA to the Superior Colliculus

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Creator: 

Schumacker, Kayla Stephanie

Date: 

2021

Abstract: 

The zona incerta is important for anxiety-mediated behaviors. It contains a group of dopaminergic cells that coexpress the vesicular GABA transporter, potentially coreleasing dopamine and GABA. The superior colliculus is a known projection site of the zona incerta and supports anxiety-driven behavior. However, it is not known if dopaminergic zona incerta cells innervate the superior colliculus via dopamine and GABA transmission. We expressed channelrhodopsin in zona incerta neurons of Th-cre mice, and their fibres were restricted to the medial motor-related layers of the superior colliculus. The superior colliculus cells received monosynaptic GABA transmission from the zona incerta, and these connected cells were dopamine responsive. These results indicated a direct connection between the zona incerta dopamine-GABA cells and the medial motor layers of the superior colliculus. These results are important in understanding the role of the zona incerta dopamine-GABA cells in the regulation of anxiety-related behaviors in the superior colliculus.

Subject: 

Neuroscience

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Neuroscience

Parent Collection: 

Theses and Dissertations

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