Due to continually increasing operating frequencies previously neglected effects of interconnects such as delay, crosstalk and attenuation are becoming major bottlenecks in high-speed designs. Effect of crossing trace angle on signal integrity of differential edge-coupled stripline is studied in this thesis. In this thesis, an efficient modeling and analysis method is presented for high-speed interconnects represented by differential asymmetrical transmission lines with oblique crossings. The method is based on dividing the structure into several sections, then using an appropriate technique for estimating the capacitance matrix of each section and subsequently evaluating the impedance matrix using the chain parameters. The thesis also investigates the implication of different angles for crossing traces on signal integrity metrics.