Stressor induced variations of mesolimbic and mesocortical intracranial self-stimulation in the DBA/2J mouse strains : therapeutic and prophylactic effects of antidepressant administration
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The appearance of ICSS alterations following acute shock exposure provides further support for the contention that neurochemical systems which contribute to motivational/reward states in the mesolimbic/mesocortical system are influenced by exposure to uncontrollable stressors. The provocation of response alterations in the ICSS paradigm in the DBA/2J mice, a strain which has been demonstrated to be uninfluenced by stressor application in the shuttle escape paradigm is consistent with the view that mouse strains vary in behavioral vulnerability to stressors, presumably as a result of strain specific variability in neurochemical alterations. Taken together, these data suggest that although pharmacological intervention with a particular agent may be ineffective in alleviating behavioral disruption, a combined antidepressant therapy which may effect neurochemical lability in a cascading fashion might ameliorate stressor provoked performance alterations.
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This work is available on request. You can request a copy at https://library.carleton.ca/forms/request-pdf-copy-thesis
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Copyright © 1989 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 1989
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