Stressor re-exposure effects on behaviour and expression of pro-inflammatory cytokines in male and female mice

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Creator: 

Hudson, Stephanie Patricia

Date: 

2014

Abstract: 

The neurochemical effects of stressful events involve a range of adaptive responses to environmental challenges. However, repeated stressors may result in the development of psychopathologies such as anxiety and depression. The immune signaling molecule, pro-inflammatory cytokines, has been linked to the development of such illnesses. Interestingly, distinct differences in stressor responsiveness exist between the sexes, alongside a much higher rate of affective disorders in females. In the present experiments we examined if repeated exposure to stressors would impact male and female CD-1
mice differently with respect to behaviour as well as cytokine expression. Repeatedly stressed males demonstrated impulsive behaviour along with sensitized IL-1β expression. In follow-up experiments the role of 17β-estradiol was examined, with stressed males that were exposed to estrogen showing reduced TNF-α expression while similarly treated females had a drastic elevation in IL-6. The current results demonstrate the differences in the stressor response system between the sexes.

Subject: 

Neuroscience
Behavioral
Psychobiology

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Neuroscience

Parent Collection: 

Theses and Dissertations

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