Stressor re-exposure effects on behaviour and expression of pro-inflammatory cytokines in male and female mice
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The neurochemical effects of stressful events involve a range of adaptive responses to environmental challenges. However, repeated stressors may result in the development of psychopathologies such as anxiety and depression. The immune signaling molecule, pro-inflammatory cytokines, has been linked to the development of such illnesses. Interestingly, distinct differences in stressor responsiveness exist between the sexes, alongside a much higher rate of affective disorders in females. In the present experiments we examined if repeated exposure to stressors would impact male and female CD-1 mice differently with respect to behaviour as well as cytokine expression. Repeatedly stressed males demonstrated impulsive behaviour along with sensitized IL-1β expression. In follow-up experiments the role of 17β-estradiol was examined, with stressed males that were exposed to estrogen showing reduced TNF-α expression while similarly treated females had a drastic elevation in IL-6. The current results demonstrate the differences in the stressor response system between the sexes.
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Copyright © 2014 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2014
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hudson-stressorreexposureeffectsonbehaviourandexpression.pdf | 2023-05-04 | Public | Download |