Metabotropic Glutamate Receptor 5 Negative Allosteric Modulation Effects on Microglia Phenotype

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.

Creator: 

Curtis, Natasha Ari Suey Lin

Date: 

2021

Abstract: 

Microglia are the resident immunocompetent cells of the central nervous system (CNS). They are extremely plastic and are critical for neurogenesis, circuit structure and function, and play a crucial role in early synapse formation. It is thought that metabotropic glutamate receptor 5 (mGluR5) plays a role in the modulation of microglial phenotype. In this thesis, we assessed the impact of the mGluR5 acting negative allosteric drug, (2-chloro-4-[2[2,5-dimethyl-1-[4-(trifluoromethoxy) phenyl] imidazol-4-yl] ethynyl] pyridine (CTEP), alone and the context of the inflammatory endotoxin, lipopolysaccharide (LPS) upon BV2 cells. This was done to assess if mGluR5 plays a role in microglia phenotype modulation. It was found that LPS has an effect on the expression of mGluR5, but otherwise did not have a significant impact upon other markers. This thesis is a starting point for future studies that seek to determine the role of mGluR5 glutamatergic signaling upon microglial phenotype.

Subject: 

Neuroscience

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Neuroscience

Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).