Metabotropic Glutamate Receptor 5 Negative Allosteric Modulation Effects on Microglia Phenotype
Public Deposited- Resource Type
- Creator
- Abstract
Microglia are the resident immunocompetent cells of the central nervous system (CNS). They are extremely plastic and are critical for neurogenesis, circuit structure and function, and play a crucial role in early synapse formation. It is thought that metabotropic glutamate receptor 5 (mGluR5) plays a role in the modulation of microglial phenotype. In this thesis, we assessed the impact of the mGluR5 acting negative allosteric drug, (2-chloro-4-[2[2,5-dimethyl-1-[4-(trifluoromethoxy) phenyl] imidazol-4-yl] ethynyl] pyridine (CTEP), alone and the context of the inflammatory endotoxin, lipopolysaccharide (LPS) upon BV2 cells. This was done to assess if mGluR5 plays a role in microglia phenotype modulation. It was found that LPS has an effect on the expression of mGluR5, but otherwise did not have a significant impact upon other markers. This thesis is a starting point for future studies that seek to determine the role of mGluR5 glutamatergic signaling upon microglial phenotype.
- Subject
- Language
- Publisher
- Thesis Degree Level
- Thesis Degree Name
- Thesis Degree Discipline
- Identifier
- Rights Notes
Copyright © 2021 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Date Created
- 2021
Relations
- In Collection:
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
curtis-metabotropicglutamatereceptor5negativeallosteric.pdf | 2023-05-05 | Public | Download |