Pressurized Metered-Dose (pMDI) Aerosol Spray Deposition in Large-and Medium-Volume Spacers
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Spacers are typically used with pMDIs by patients suffering from chronic lower respiratory tract diseases such as asthma. Deposition of medication, salbutamol sulphate, was studied in a medium- and large- volume spacer, namely, the Volumatic™ and OptiChamber® spacer. Experiments were conducted at inspiratory flow rates ranging from 30 to 60 L/min, and deposition of medication in the spacers were assessed using spectrophotometry. Computational fluid dynamics was used to quantify the deposition (and its mechanism) numerically at 30 L/min. Medication deposition in the spacers was found to be greater in the lower half due to a downward spray angle. Additionally, it was determined more deposition of medication could be expected in the distal half of the spacers. An increase in flow rate demonstrated a minimal increase (2-3%) in the medication delivered to the inline filter. The numerical analysis demonstrated that turbulence effects are likely to cause deposition in both spacers.
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Copyright © 2020 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2020
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ogrodnik-pressurizedmetereddosepmdiaerosolspraydeposition.pdf | 2023-05-05 | Public | Download |