Characterization and Application of a Histamine Aptamer-Based Biosensor

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Iraganje, Elysee




Histamine is a biogenic amine, identified as a natural contaminant in food and alcoholic beverages, with high levels eliciting allergy-related conditions. Exposure to allergens can lead to abnormal high levels of histamine in the body that is detectable in blood and urine. A rapid histamine biosensor that can detect histamine levels in food, beverages and also be used as a diagnostic tool for allergy-related conditions will be an ideal point of care testing tool. In addition, histamine has been identified as a close-range aggregation pheromone component in bed bug feces. A portable biosensor that detects bed bugs in these settings is in demand. Nano-aptamer based biosensors have previously been used to detect wide range of targets. In this study, histamine-binding aptamers were characterized. A head-to-head comparison of binding affinity and specificity for these group of aptamers were conducted, and the aptamer candidates best suited for biosensor application was selected.


Analytical Chemistry
Inorganic Chemistry




Carleton University

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