Retrospective Analysis of Permanent Prostate Implants Based on Patient-Specific Monte Carlo Dose Calculations

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.


Haidari, Ali-Reza Mehan




Current dose calculations for permanent prostate implant brachytherapy are performed using the American Association of Physicists in Medicine TG-43 formalism, where dose distributions are derived for a homogeneous water phantom in the absence of inter-seed effects. Using a model-based approach, this study investigates differences in dosimetry, radiobiological endpoints, and clinical outcomes, compared to the clinical TG-43 formalism. Post-implant CT images are used to derive unique virtual patient phantoms (water- and tissue-based) for a cohort of patients. With the use of the Monte Carlo (MC) approach to dose calculations, radiation transport and dose deposition is simulated in these virtual phantoms. Dose and volume metrics are extracted for all the patients and comparisons between the tissue- and water-based approaches are made. Dosimetric quantities are shown to vary between the tissue- and water-based approaches for the prostate and organs-at-risk, with dose overestimation of up to 9.12% in the prostate using the water-based approach.


Physics - Radiation




Carleton University

Thesis Degree Name: 

Master of Science: 

Thesis Degree Level: 


Thesis Degree Discipline: 


Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).