Effects of Chronic Prenatal Adversities on the Adult Response to a Social Stressor

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.

Creator: 

Paric, Angela

Date: 

2014

Abstract: 

It was hypothesized that prenatal stressor effects persist into adulthood and would be particularly notable following re-exposure to an adult stressor. Pregnant mice were stressed for 12 days and adult offspring underwent a social stressor. Following the adult treatment, exploratory and social behaviour, and plasma corticosterone (CORT) levels were observed in addition to cytokine, corticotropin releasing hormone (CRH), and CRH receptor messenger RNA (mRNA) expression in the prefrontal cortex (PFC). Increased and decreased anxiety-like behaviour was observed in males and females,
respectively. Also, elevated CORT was detected in prenatally stressed males and females while increased pro-inflammatory cytokines, CRH, and CRH receptor 1 (CRHR1) in the PFC were mainly observed in prenatally stressed females. These findings suggest gender dimorphic effects of maternal stress on behaviour and PFC cytokine, CRH, and CRHR1 expression that may impair stress and emotional regulation in the offspring.

Subject: 

Neuroscience

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Neuroscience

Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).