Enhancing Folic Acid Dietary Intervention Research in Mouse Models

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.

Supplemental Files: 


Munezero, Esther




Folic acid is associated with both beneficial and potentially adverse effects. Characterization of safe and adequate FA intakes is important. Animal-derived data play an important role in the elucidation of the mechanisms linked to FA intake. However, poor reporting of study details hinders knowledge translation. My first study was a scoping review to determine the reporting quality of studies examining the effects of dietary FA interventions in mice. Our findings showed that 14% of studies did not report ≥1 generic reporting item(s) and 41% did not report ≥1 nutrition- specific reporting item(s). This incomplete reporting limits generalizability and interpretation. The second study was designed to establish biomarkers of FA intake and function in mice. I identified homocysteine concentration ≥ 3.88 umol/L as a functional marker of deficiency and unmetabolized FA concentrations ≥ 7.71 nmol/L as a marker of excess FA intake. These observations can inform future study designs.






Carleton University

Thesis Degree Name: 

Master of Science: 

Thesis Degree Level: 


Thesis Degree Discipline: 


Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).