Chemical control of the mixed function oxidase system and its implications in determining biological hazard

Creator: 

Brownlee, Lorna Jean

Date: 

1990

Abstract: 

Risk assessment is the process of determining chemical tolerance limits in the environment and can be defined as Z Hazards x L Exposures. Hazard can be factored into two responses to a chemical: cellular damage by the chemical and repair/protection by the host. The Mixed Function Oxidase system is very responsive to xenobiotics and may reflect hazard. A recent electrophilic SE2 mechanism suggested that this was the result of a relationship between the oxidation potential of the induced MFO active site and the C-H bond strength of xenobiotic. This study tested and supported this model of enthalpic biochemical control, demonstrating that an induced active site has the potential to metabolize any C-H bond that is weaker than the C-H bond strength of its inducer. Chlorinated chemicals exhibited a stronger oxidation potential than predicted, presenting a risk of uncontrolled oxidations that may initiate chemical disease.

Subject: 

Oxidases
Risk Assessment

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Chemistry

Parent Collection: 

Theses and Dissertations

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