Evaluation of Antimicrobial Activity of Fourteen Medicinal Basidiomycete Fungi against Yeast and Antibiotic Resistant Esherichia coli
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Bacterial resistance to antibiotics is a growing concern to society and treatments require the discovery of new antimicrobial compounds. This study evaluated fourteen different edible and/or medicinal mushroom species for antimicrobial activity. Growth inhibition of Saccharomyces cerevisiae, and of ciprofloxacin-resistant strains of Escherichia coli was examined using bioassays and by Minimum Inhibitory Concentration with alcohol extracts of mushroom mycelia and culture broth. Cultures used for extract preparations were grown in Potato Dextrose Broth with or without induction using a) low-nutrient medium, b) spent Escherichia coli filtrate, or c) 5-azacytidine. Several extracts resulted in a reduction in bacterial and/or yeast growth, although full inhibition was observed with only a few extracts. Fungi with antimicrobial activity may be useful as a food therapy as well as leads in drug discovery and this study confirms that basidiomycetes may provide new, useful antimicrobials.
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Copyright © 2017 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2017
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tabaja-evaluationofantimicrobialactivityoffourteen.pdf | 2023-05-05 | Public | Download |