Peripheral biomarkers in Repeated Ketamine Infusions Trial
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Abnormalities in the endocrine and immune systems are well documented in patients with Major Depressive Disorder (MDD), however, the mechanisms by which the novel antidepressant treatment, ketamine, influences these physiological systems are unclear. This study examined the effects of repeated ketamine infusions on the endocrine and immune systems using the peripheral biomarkers C-reactive protein (CRP) and cortisol. While both depressive symptoms and suicidal ideation were reduced with repeated ketamine treatment, there was no significant change in plasma CRP levels throughout the clinical trial. Morning salivary cortisol did change throughout the clinical trial in a sex-dependent way. Further sex-specific investigation into ketamine's effect on glucocorticoid expression is needed to advance the knowledge of the underlying mechanisms of ketamine's rapid antidepressant effects to more effectively treat patients with depression.
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Copyright © 2021 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2021
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vangeel-peripheralbiomarkersinrepeatedketamineinfusions.pdf | 2023-05-05 | Public | Download |