Neuroinflammation and Parkinson’s Disease: Understanding the Inflammatory Process Induced by Chronic Peripheral Injection of LPS in LRRK2 G2019S KI Mice in Correlation with Age

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Dinesh, Anuroopa




Parkinson' disease is a progressive neurodegenerative disease arising from a collective effect of advancing age, genetic vulnerabilities and environmental toxins. The objective of the current study was to elucidate a synergistic effect of the advanced age, G2019S mutation and immunological stress (LPS) on neuroinflammation. In the present study, male mice were given five intraperitoneal injections of 250mg/kg of LPS (or saline) every alternate day across the two levels of the age and genotype (age; old vs young, genotype; WT vs G2019S). In line with our expectation, there was a significant loss of TH+ cells in old-G2019S mice that received LPS compared to the young-WT that received saline. There was a significant effect of age and genotype on baseline locomotor activity of these animals. Age and genotype predominantly affected other aspects like increased CX3CR1 expression and increased SiRT3 expression in SNc.






Carleton University

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