Exploring the Neuroplastic and Antidepressant-Like Effects of Erythropoietin
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A growing body of evidence implies that depression may arise in part through a deregulation of neuroplasticity, and novel antidepressants have shown therapeutic potential by exerting neurogenic and neuroplastic effects. The hematopoietic cytokine erythropoietin (EPO) has shown antidepressant potential with an ability to regulate neuroplastic and cognitive-behavioral outcomes. This research sought to further the knowledge of the antidepressant potential of EPO through cellular and behavioral outcomes. In Exp 1, effects of 2 week EPO administration on chronically stressed rodents (an animal model of depression) was observed by the forced swim test (FST) and doublecortin immunohistochemistry for immature granule cells. In Exp. 2, whether acute EPO administration has the potential to synergize with an SSRI was analyzed using the FST. This research showed no effect of EPO on cellular or behavioral outcomes, suggesting a necessity for further studies of this paradigm utilizing alternative models or methods to those used here.
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Copyright © 2015 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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