The Effect of Environmental Heterogeniety on the Fitness of Antibiotic Resistant Escherichia Coli
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The cost of antimicrobial resistance (AMR) is the reduction of fitness of a resistant mutant relative to a susceptible strain in the absence of drug. Costs of resistance are usually estimated in a single environment and on one genetic background; these fitness estimates may not be representative of what happens in nature. I measured the fitness of AMR E. coli strains in different environments, including medically and ecologically relevant ones. To do this, a collection of AMR strains of Escherichia coli bearing a single resistance mutation were competed against their ancestral strain in 10 different media. The results of this study indicate that laboratory media does not predict fitness in natural environments. We found environments in which resistance alleles suffered no cost, suggesting that these mutants may persist for long periods of time. Data on the fitness of AMR pathogens across environments will help manage their spread.
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Copyright © 2018 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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