Effects of a Northern Contaminant Mixture, Diet, and Body Weight on Glucose and Cholesterol Metabolism and Lipoprotein Signaling in JCR Rat Liver
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Northern Canadian populations (specifically the Inuit) display higher prevalence of diabetes and cardiovascular diseases. It is believed that diet and lifestyle contribute to the development of these disease; however, recent epidemiological studies suggest that persistent organic pollutants and heavy metals may also contribute to the development of these diseases. In this study, we outline the effects of these chemicals and the consumption of high fat/sugar food on glucose and cholesterol metabolism and lipoprotein signaling in JCR rat liver. Using gene profiler arrays, we have identified four genes that are affected mainly by these contaminants and/or diet. Our results indicate that these mixtures alter the expression of genes in gluconeogenesis pathway (fructose 1,6-bisphosphatase and pyruvate carboxylase), a protein involved in cholesterol transport (apolipoprotein A1), and a transcription factor that is responsible for the expression of proteins in lipogenesis pathway (sterol regulatory element binding transcription factor 1).
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Copyright © 2016 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2016
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almohaisen-effectsofanortherncontaminantmixturedietand.pdf | 2023-05-04 | Public | Download |