Biomimetic architecture possesses tremendous potential for techno-ecological synergy, yet it currently lacks a strong philosophical foundation. Freya Mathews attributes synergy in nature to two fundamental principles of life: conativity and least resistance. In the pursuit of techno-ecological synergy, biomimetic designers need to embrace these concepts. This can only be accomplished through the rejection of the anthropocentric and technological dogmas of modernity in favor of bioinclusivity. While architects and researchers have begun to address this difficult task, an examination of architectural precedents reveals the investigative directions needed. The philosophical exploration undertaken in this thesis informs a biomimetic design strategy for the actualization of William Commanda’s vision for Victoria Island. The design of the Asinabka Indigenous Cultural Centre reinforces the synergistic potential of biomimicry through the integration of the Indigenous worldview. These concepts culminate in an arboreal structure embodying interconnectedness and in a roof garden promoting a renewed encounter with nature.