Analysis of interneurons of the rat piriform cortex : morphology, innervation, calcium binding protein expression and co-expression
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Piriform cortex (PC) receives sensory input from olfactory areas, passes this onto cortical/subcortical structures and is integrated with behavioural modalities. Little is known about functional/anatomical connections of the PC. Sensory/behavioural olfactory pathways and altered interneuron wiring may facilitate the region's seizurogenic tendencies. Innervation-pattern description of the various interneurons was the objective.Distinct interneurons express differing calcium binding proteins (CBPs). Antibodies against these were used to characterise interneuron anatomical/morphological/innervation patterns. Parameters investigated for each interneuron subtype were: laminar distribution; CBP expression overlap; dendritic arborization patterns; and post-synaptic targets of nerve terminals (NTs). These were quantified to establish a baseline, and combined to identify subtypes within the CBP-expressing groups.Only PV and CB were co-expressed in interneurons. For each subtype specific laminar distribution of somata/dendritic processes/NTs; specific dendritic arborization patterns and post-synaptic morphological targeting was found. Findings were examined within context of olfactory processing, seizurogenesis and existing olfactory cortex connectivity models.
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This work is available on request. You can request a copy at https://library.carleton.ca/forms/request-pdf-copy-thesis
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Copyright © 2007 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2007
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