Development of Biocompatible Aptamer Films as Smart Materials for Novel Fertilizer Systems
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Aptamers are short, single stranded nucleic acids that fold into well-defined 3D structures which bind to a single target molecule with affinities and specificities that can rival antibodies. The compatibility of aptamers with nanostructures such as thin films, in combination with their inherent properties could set the foundation for the development of smart materials. This research will focus on development of a biocompatible aptamer-polyelectrolyte film system for use in controlled-release applications. We demonstrated the ability of the sulforhodamine B aptamer to function while sequestered in a chitosan-hyaluronan film matrix. Our results also suggest that deposition conditions play a strong role in the internal film interactions and growth mechanism. As a secondary objective, the protective role of the polyelectrolytes against nuclease-mediated aptamer degradation was investigated. This research has the potential to revolutionize materials used in controlled-release platforms with possible application to fertilizer systems which will be discussed.
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Copyright © 2014 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2014
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foster-developmentofbiocompatibleaptamerfilmsassmart.pdf | 2023-05-04 | Public | Download |