The effects of catecholamine depletion and acute noradrenaline replacement on amygdala kindling in the rat.

Creator: 

Collins, Barbara.

Date: 

1985

Abstract: 

Depletion of catecholamines (CAs) with intraventricular 6-hydroxydopamine (6-OHDA) has been repeatedly demonstrated to exert a profound facilatory influence on the rate of amygdala kindling in the rat. Since the  depletion of noradrenaline (NE) effected by this neurotoxin is thought to mediate this acceleration in seizure development, it was hypothesized that acute administration of intraventricular NE prior to kindling stimulations would reverse this effect.

Male Wistar rats were pretreated with either intraventricular 6-OHDA or with the vehicle solution alone (VEH) and implanted with amygdala electrodes bilaterally. Following a minimum recovery period of three weeks, kindling was begun. Prior to each kindling stimulation, 6-OHDA and VEH animals received intraventricular infusions of either NE or the saline-ascorbic vehicle (ASC).

Pretreatment with 6-OHDA was once again found to facilitate the rate of kindling but, contrary to prediction, exogenous NE failed to reverse this effect. NE did however appear to retard kindling in VEH pretreated animals. These results are interpreted as evidence that the well-established seizure suppressive influence of NE is mediated presynaptically, presumably by the inhibitory α2 receptor.

Subject: 

Amygdaloid Body
Catecholamines
Noradrenaline

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Arts: 
M.A.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Psychology

Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).