Structural Development of Hippocampal CA3 Pyramidal Neurons and Relation to the Development of Spatial Learning and Memory in Rats
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The dentate gyrus-CA3 circuit in the hippocampus is highly plastic during development and morphologically responsive to various environmental outputs. The current study investigated the structural changes in CA3 pyramidal neurons during development (p18-p24) and the effect of AMPA receptor antagonism on spatial learning and memory. Exp.1 showed individual changes in the elements of CA3 pyramidal neurons. Some parts expanded with age and others retracted. Golgi analysis revealed a reduction in spine density and an increase in thorny excrescences (TE), suggesting a role for TE in spatial abilities that emerge at the same age. Exp.2 investigated the effect of AMPAr antagonism (NBQX) on spatial function and on CA3 pyramidal neuron structure. NBQX-injected rats showed impaired spatial abilities and individual remodeling in different components of CA3 pyramidal neurons including an increase in spines density and a decrease in TE. This suggest a role for TE in mediating spatial learning and memory.
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Copyright © 2015 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2015
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mahdi-structuraldevelopmentofhippocampalca3pyramidal.pdf | 2023-05-04 | Public | Download |