Investigating the Associations Between Brain Network Functional Connectivity and Health-Related Quality of Life Following a Pediatric Concussion
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Concussions negatively affect adolescent health-related quality of life (HRQoL) for months post-injury. Functional connectivity (FC) within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) has shown alterations post-concussion. The present study explored whether FC differs between concussion and orthopedic injury (OI) groups aged 10-18 and if associations exist between FC and HRQoL 4-weeks post-concussion. Resting-state functional MRI (rs-fMRI) and HRQoL measurements were completed 4-weeks post-injury. One-way ANCOVA analyses were conducted between groups with network FC. Multivariate linear regressions assessed associations between connectivity and HRQoL. A total of 55/72 concussion and 27/30 OI participants were included. FC was increased within the CEN and SN, between the DMN-SN and CEN-SN, and decreased between the DMN-CEN in the concussion group. No significant associations were found between HRQoL and FC. Differential connectivity patterns exist 4-weeks following pediatric concussion, however, they are not associated with HRQoL.
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Copyright © 2021 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2021
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healey-investigatingtheassociationsbetweenbrainnetwork.pdf | 2023-05-05 | Public | Download |