Hybrid simulation is an innovative testing technique which takes both advantages the efficiency in numerical modelling and accuracy of physical test. This research presents a framework for assessing the risks of large-scale structures in fire and fire following earthquake through hybrid simulation. Full interactions between the thermal and mechanical behaviour of the structures are considered in the assessment. In the proposed framework, the element of the prototype structure that is exposed to the sequence of fire loads is selected as physical domain for physical test while the remainder structure as numerical domain is numerically modelled. An illustrative example of the building exposed to fire hazard is presented to demonstrate the hybrid fire simulation methodology. For the multi-hazard risk, a numerical study on the performance of a 4-storey steel moment resisting frame subjected to fire following earthquake is also presented in this research.