Extended Release of DTPA via Encapsulation into Nanoparticles for the Decorporation of Deposited Radioactive Contaminants in the Lungs
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Diethylenetriaminepentaacetic acid (DTPA), in either H-, Zn- or Ca-form, is a complexing agent that has been approved by the U.S. Food and Drug Administration (FDA) for the decorporation of radioactive actinides such as americium, curium, and plutonium following a radiological incident. However, DTPA is excreted rapidly from the body following administration, which limits its ability in removing intracellularly bound actinides. In this research project, DTPA loaded polyethylene glycol (PEG) functionalized TiO2 nanoparticles, Zn-DTPA encapsulated poly lactic-co-glycolic acid (PLGA), and Zn-DTPA encapsulated lecithin liposomes were tested for extended release of DTPA in vitro. Furthermore, the toxicity of Zn-DTPA encapsulated lecithin liposomes has been confirmed to be nontoxic in the cytotoxicity study of Long Evans rats. Meanwhile, the efficacy of Zn-DTPA encapsulated liposomes in the decorporation of 241Am, 243/244Cm, and 238/239/240Pu from their lungs after intranasal administration is under evaluation.
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Copyright © 2020 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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- 2020
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almalki-extendedreleaseofdtpaviaencapsulationinto.pdf | 2023-05-05 | Public | Download |