This study focuses on the aerodynamic interaction of a strut and a row of guide-vanes located in the inter-turbine duct (ITD) of a typical turbofan gas-turbine engine in the context of optimizing their relative positioning to minimize the total profile loss. The study was intended to use numerical analysis to determine promising axial and pitchwise positions of the strut relative to the guide-vane row to create a test matrix for further experimental study. For this analysis, the Baseline (BSL) Reynolds-stress turbulence model was used in a series of benchmarking exercises using published and experimental low-speed wind-tunnel data. The BSL model was found to be limited in its ability to accurately generate the flow physics in a free-shear layer despite being capable of approximating the momentum thickness in the wake of a strut and guide-vane row in tandem configuration and the mixing-layer growth rate of a planar turbulent free-shear layer.