Brain Derived Neurotrophic Factor (BDNF) as a Mediator of Microglia-Induced Neuroinflammation

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Creator: 

Charlton, Tryston Jarred

Date: 

2022

Abstract: 

Microglia are the primary immunocompetent cells that protect the brain from environmental stressors; however, their activation can also have deleterious effects on brain functioning. Indeed, environmental toxins and microbial agents can induce microglial driven inflammatory processes and induce a cytotoxic environment. Recent therapeutic strategies have sought to determine how to modulate microglia, to favour their neuroprotective effects, while minimizing toxic outcomes. We hypothesized that BDNF would have a modulatory effect on inflammation in isolated microglia cultures in the context of a bacterial endotoxin. It was found that a BDNF treatment following LPS-induced inflammation blunted the release of both IL-6 and TNF-α in primary microglia. In neurons, LPS-activated microglial media was able produce an inflammatory effect to some extent, and again, BDNF treatment attenuated this effect. We speculate that BDNF plays a role in regulating microglia activation and localized microglia-neuron crosstalk may be crucial in preventing damaging effects of inflammatory mechanisms.

Subject: 

Neuroscience
Immunology

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Neuroscience

Parent Collection: 

Theses and Dissertations

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