To meet the demands for reducing building energy consumption, the insulation level of building envelopes is being increased, by increasing the thickness of building walls or through using better performing materials. Vacuum insulation panels (VIPs) have showed potential for use in buildings as they provide significant insulation levels in thin profiles. VIPs lose thermal performance over time as moisture and air permeate into the panel. A shortcoming of current research is how weather and construction impacts VIP lifespan. This thesis will focus on the use of weather data to model the conditions a VIP is subjected to in a wall, and a lifespan prediction based on these conditions. Including, the construction of a hygrothermal model to simulate the conditions in a wall over a 25-year period. For the Ottawa and Niagara climates, the predicted VIP lifespans were 22.6/19.0 and 23.6/19.6 years for the retrofit and new constructions, respectively.