The Acquisition and Expression of Remote Spatial Memories Formed During the Juvenile Period are Impaired by AMPAr Blockade

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Tzakis, Nikolaos




The current work investigated the effect of AMPAr blockade on the emergence and expression of spatial function and neural activity patterns in the brain. Pretraining administration of the AMPAr antagonist, NBQX, impaired acquisition of the platform location. Posttraining administration of NBQX had no effect on day-to-day performance. When given a probe test, saline groups across all conditions spent more time in the target quadrant. The pretraining and pretesting, but not the posttraining or pretraining/pretesting, 5 mg/kg NBQX group showed a preference for the target quadrant. Pretraining, posttraining, and pretaining/pretesting, but not pretesting, 10 mg/kg NBQX groups did not show a preference for the target quadrant. c-Fos labeling in the hippocampus reflected differences in probe performance while ACC c-Fos labeling reflected acquisition data. Results indicate that AMPAr activation is necessary for the acquisition and expression of remote spatial memories and that hippocampus activation is required for the expression of those memories.


Psychology - Cognitive




Carleton University

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