The Use of Diazomethane to Enhance the Selectivity of Bisphenol A Imprinted Polymers

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.

Click here to download the PDF file.

Creator: 

Alenazi, Noof

Date: 

2014

Abstract: 

Bisphenol A (BPA) is an estrogen-mimicking chemical that can be selectively extracted from water using a molecularly imprinted polymer (MIP). However, the presence of non-specific binding sites has thusfar limited the utility of BPA-MIPs in sensor applications. This project explored two approaches to reduce or eliminate these sites: Optimizing the molar ratio of functional monomer (methacrylic acid) to cross-linker (ethylene glycol dimethacrylate) to template, or partially esterifying the carboxylic acid residues by site-selective chemical modification via treatment with diazomethane. Results
show esterification with diazomethane to be more efficient in blocking non-specific binding sites than optimization of the template to monomer to crosslinker molar ratio. The efficiency and selectivity of the diazomethane-treated molecularly imprinted polymer (TMIP) particles were then compared with those of a commercially available MIP, either uniformly dispersed in the sample solution or densely packed into a cartridge, for solid phase extraction.

Subject: 

Analytical Chemistry
Organic Chemistry

Language: 

English

Publisher: 

Carleton University

Thesis Degree Name: 

Master of Science: 
M.Sc.

Thesis Degree Level: 

Master's

Thesis Degree Discipline: 

Chemistry

Parent Collection: 

Theses and Dissertations

Items in CURVE are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with permission from the author(s).